Particle Therapy 2017

1366-1367 / 2605

Phases of clinical research (1)
• Preclinical testing
– In-vitro, in-vivo
– Phantoms, cadavers
• Phase-0
– Surrogate endpoints
• Pharmacokinetics, pharmacodynamics
• Imaging, blood or tissue analysis
• In-silico
– ≤ 10 patients (trend in radiotherapy >10
patients)