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Optimization of CIRT

Via dose escalation

•Concurrent chemo

•Serial OAR

•Low α/β of OARs

•Examples

Pancreatic

Recurrent rectal

Skull-base

HCC(porta)

Via hypofractionation

•Small PTV or

radiosensitive tumor

•Parallel OAR

architecture

•High α/β of OARs

•Examples

NSCLC

HCC(peripheral)

Kamada T, et al. Lancet Oncol. 2015 Feb;16(2):e93-e100