Optimization of CIRT
Via dose escalation
•Concurrent chemo
•Serial OAR
•Low α/β of OARs
•Examples
–
Pancreatic
–
Recurrent rectal
–
Skull-base
–
HCC(porta)
Via hypofractionation
•Small PTV or
radiosensitive tumor
•Parallel OAR
architecture
•High α/β of OARs
•Examples
–
NSCLC
–
HCC(peripheral)
Kamada T, et al. Lancet Oncol. 2015 Feb;16(2):e93-e100