Hypofrac)ona)on
Dose escala)on
Architecture
Serial
Paralle
l
Organs-at-risk (low LET)
Liver, kidneys
Porta, extrahepatic bile ducts
Spinal cord,
stomach, intestine
α/β
Low
High
Conc chemo
Yes
No
CIRT hypofrac)ona)on or dose escala)on?