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CIRT

hypofrac.ona.on

or dose

escala.on? Hypofrac.ona.on

Dose

escala.on

Tumor

High LET: little fractionation effect

High tumor control?

No

Yes

CIRT

(43.2 GyE)

+ GEM

(1000 mg/m²)

Local tumor control 25% at 2 year