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Although LET levels were higher in symptomatic treatment change areas,
no clear
correlation was found
between the sites of injury and elevated RBE due to higher LET.
Increasing evidence for increased clinical RBE
Giantsoudi et al, IJROBP, 2015;
CNS Injury for 111 pat. treated w. p-RT: LET, RBE associations for
areas of Injury
RBE weighted dose for
= 1.5 (thin dashed), 2.1(fat) or 2.8Gy (thick dashed)