1424-1425 / 2605
modified from :
Bentzen SM Nat Rev Cancer 6: 2006
Release/activation of
downstream cytokines,
growth factors or chemokines
pathogenesis of radiation-induced late
damage
Early
events
Chronic events
Orchestrated
biological
response
. . . mediated by
inflammatory,
stromal, endothelial
and parenchymal cells
IR
Cytokine cascades
are
continually perpetuated
Activation of
proangiogenic
and
profibrogenic cytokines
leading to
tissue damage and fibrosis
vascular
damage
hypoxia
macrophages
ROS
Inflammation