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ionizing radia*on is an efficient inducer of
DBS breaks
which
can result in chromosomal aberra*ons
(but not of point muta*ons !)
gross aberra*ons (e.g. dicentrics) are lethal !
transloca*ons tend to persist
Genes in new loca*ons -
altered gene expression, which can
lead to tumor progression
How does radiation cause cancer ?
Carcinogenesis
Direct
and
indirect a
ction
of ionizing radiation on DNA