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There is increasing concern about

radiotherapy-related second cancers

As younger patients are treated, with longer life expectancy,

RT-induced second malignancies

will likely assume increasing importance

Compared to the older 3-D conformal radiotherapy, modern

IMRT techniques

minimize

the amount of normal tissue getting

high doses

But IMRT does result in

larger volumes

of normal tissue

getting

lower doses

(

more fields and more leakage

)

Which is preferable in terms of second cancers ?

Small volumes of normal tissue getting high doses

(3D-CRT)

Larger volumes of normal tissue getting low doses

(IMRT)