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Radiation-induced breast cancer:
Excess relative risk at high doses
Brenner
et al
2006
JNCI 98: 1974-86 (2006)
PNAS 102:13040-5 (2005)
Mean exposure age: 23
•
IMRT minimizing high doses to normal
tissues helps
•
IMRT’s extra lower doses less important
total dose
High doses do matter