1454-1455 / 2605
Relative Biological Effectiveness of Carbon Ion Radiation for
Induction of Rat Mammary Carcinoma
7–8-week-old rats (
ACI, F344, Wistar,
and
Sprague-Dawley
) after irradiation
(
0.05–2 Gy
) with 290 MeV/µ 12C ions with a SOBP (LET
40–90 keV/µm
)
12C radiation induced rat mammary carcinomas in a strain- and
dose-dependent manner
A
t lower LET, the 12C effects are more similar to photon
irradiation
RBE value of 2
is appropriate for risk estimation of
therapeutic