Patient:
age
comorbid conditions
inter-individual radiosensitivity
smoking
Organ:
organization (serial/parallel)
regional variation of radiosensitivty
impact of other organs
Treatment:
Endpoints:
dose
(max, min, mean)
fractional dose
overall treatment time
beam quality
treatment volume
clinical
(acute, late)
morphological, functional
degree of severity
impact on quality of life
Emani 2013, Rep Radiother Oncol
Variables that can impact normal
tissue tolerance in patients