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‘
M1
’ produce
reac.veoxygen species
(ROS)
par.cipate in Th1 (T-helper cell)
T cell mediated immunity responses
and have an.-tumor ac.vity
‘
M2
’ have different cell surface
receptors,
produce different cytokines and are
more involved in .ssue remodeling +
angiogenesis
Macrophages
Immunological “keyplayers”
➢
Cytotoxic T cells
recognize Ag on CC and kills them
➢
Natural Killer
Cells
cri.cal to innate immune system
Tumor cells down-regulate an.gens
that cause them to be recognized