610-611 / 2605
Indirect effects: immunity
alters
composition of
cellular immune
infiltrates
Some evidence that
hypofractionation shifts
immunological effects to positive
increase
immuno-
suppressive
capacity
tumor
microenvironment
positive
negative
upregulation of MHC
antigens ?
activation of tumor-
specific T-cells (CD8+)
able to perform killing ?
more damage due to direct
& indirect effects