1704-1705 / 2953
LKB model
The Lyman-Kutcher-Burman (LKB) model uses an Equivalent Uniform Dose
(EUD)*:
D
i
= total dose to bin
i
V
i
= absolute volume in bin
i
V
tot
= total organ volume
n
= volume effect parameter
Parameter ‘n’ is organ (endpoint) specific
•
Low (≈ 0): small volume effect, EUD ≈ max dose
•
High (= 1): large volume effect, EUD = mean dose
*Original representation with
effective volume
rather than EUD
05/04/2016