2408-2409 / 2953
Late Toxicity
RTOG G2+ bowel toxicity at 2yr 74Gy (3.8%) 60Gy( 2.9%) 57Gy (1.8%)
No significant difference at 5yr 74Gy (1.3%) 60Gy (2.3%) 57Gy (2.0%)
G2+ bladder toxicity showed NSD at 2yr or 5yr.
CHHiP Study
Analysis of LENT-SOM and PROs supported these results.
Conclusions: After 5 years follow-up treatment with 60Gy/20f is non-
inferior to 74Gy/37f for PCa progression and is not associated with
significant differences in late toxicity. 57Gy/19f has not been shown to
be non-inferior to 74Gy/37f. All schedules had a low side effect profile
using trial specified IMRT techniques. 60Gy/20f appears effective and
safe and may be recommended as a new standard of care.