2398-2399 / 2953
GI Toxicity
Dutch CKVO96-10 PMID 18718725 -- "Role of intensity-modulated radiotherapy in
reducing toxicity in dose escalation for localized prostate cancer." (Al-Mamgani A, Int J
Radiat Oncol Biol Phys
•
Dutch randomized dose-escalation trial, subset treated at same institution
to 78 Gy using 2 techniques: 3D-CRT and IMRT
•
Outcome: 5-year bPFS IMRT 70% vs 3DCRT 61% (NS)
•
Acute toxicity: G2+ IMRT 20% vs. 3DCRT 61% (SS)
G3+ 0% vs 13%
•
Late toxicity: G2+ IMRT 21% vs. 3DCRT 37% (NS); GI G3+ 0% vs 7%
G3+ 0% vs 7%
Conclusion: IMRT reduced toxicity without compromising
outcomes