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Daily rigid isocentre adaptations/IGRT:

Conclusions

Daily online adaptive concepts further

reduce

uncertainties, but

do not

remove uncertainties completely

there is still a lower limit for margin size

– treatment with ‘zero margin’ is

not safe even with online imaging efforts

too much margin reduction might be dangerous for other reasons as well:

extra-capsular extension, see Chao et al. 2006 (IJROBP 65(4))

ESTRO IMRT course 2016

Adaptive Radiotherapy

London April 7th, 2016

-39-

My personal opinion:

Even with advanced daily IGRT possibilities, there is still a need for ‘smart’

probabilistic and robust planning approaches

– beyond the margin

approach – due to the remaining uncertainties.