IMRT Course 2016

Cohorts 2 and 3: Pelvic/spinal bone sarcomas (33 patients)

Does the use of IMRT enable achievement of a

radiotherapy treatment plan that delivers the optimal dose

while keeping within normal tissue tolerances?

Primary endpoint: The proportion of patients where the

IMRiS: Intensity Modulated Radiotherapy in

Sarcoma

recommended optimal radiotherapy dose can be

achieved with IMRT

Cohort 2 (Ewing’s): Increase proportion of patients

receiving 95% of optimal dose from 70% to 90%

Cohort 3 (non-Ewing’s): Increase proportion of

patients receiving 95% of optimal dose from 0% to

50%

Secondary endpoints: Toxicity, response, quality of life,

time to local recurrence/disease progression, survival