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Cohort 1: Limb soft tissue sarcoma (110 patients)
Does use of IMRT reduce late toxicity?
Primary endpoint: rate of grade 2+ late soft tissue
fibrosis at 2 years following radiotherapy (aim to reduce
IMRiS: Intensity Modulated Radiotherapy in
Sarcoma
from 30% to 20%)
Secondary endpoints: acute and late toxicity, patient
reported limb function and quality of life, wound
complications, time to local recurrence
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