328-329 / 2953
IMRT prospective clinical trials: 1
Wound complications in 30.5% (vs 43% in SR2 study) (p=0.2,
NS)
(1)
Commonest sites: buttock, adductor and posterior
compartments of thigh
Reduced need for tissue transfer for closure
Reduced second surgery for wound complications 33% vs
43% (SR2)
Trend for increased dose to flap and increased volume of flap
receiving 50Gy in patients with wound complications
Negative result thought to be due to compromising of flap
sparing in order to ensure adequate PTV coverage
Grade 2+ fibrosis at 2 years 9.3% vs 31.5% (SR2)
Moderate joint stiffness 5.4% vs 17.8% (SR2)
(1) O'Sullivan B, Griffin AM, Dickie CI, et al. Phase 2 study of preoperative image-guided intensity-
modulated radiation therapy to reduce wound and combined modality morbidities in lower
extremity soft tissue sarcoma.
Cancer
2013;
119
(10): 1878-84.