326-327 / 2953
IMRT prospective clinical trials: 1
Phase II study to determine if preoperative IMRT is
effective in minimizing the dose to skin and subcutaneous
tissues used to close the resection site and reduce the risk
of wound complications (PMH, Toronto)
(1)
Dose was reduced to the anticipated surgical flaps by
using IMRT planning
Primary endpoint: acute wound healing within 120 days
Secondary endpoints: limb oedema and fibrosis, bone
fracture, limb function, overall patient function
70 patients 2005 – 9
Median 9.5cm, 93% G3, 98% deep to fascia
(1) O'Sullivan B, Griffin AM, Dickie CI, et al. Phase 2 study of preoperative image-guided intensity-
modulated radiation therapy to reduce wound and combined modality morbidities in lower
extremity soft tissue sarcoma.
Cancer
2013;
119
(10): 1878-84.