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2. Does the method contain
system suitability tests or
controls as specified by the
SMPR? If not, please indicate
if there is a need for such
tests or controls and which
ones.
Yes, system suitability is covered.
3. Is there information
demonstrating that the
method system suitability
tests and controls as
specified in the SMPR worked
appropriately and as
expected? If no, please
specify.
Yes, there is information supporting system suitability has been met per SMPR.
4. Based on the supporting
information, is the method
written clearly and concisely?
If no, please specify the
needed revisions.
Method is clearly written. Would like to see data around LOQ/LOD. Also, there is a
comment that centrifugation is used instead of filtration to prevent loss/binding of
catechins to filters. Would like to see data in support of this.
5. Based on the supporting
information, what are the
pros/strengths of the
method?
The method provides a rapid way to quantify seven catechins and caffeine in green tea
extracts, supplements, etc. The accuracy, linearity and selectivity is good.
6. Based on the supporting
information, what are the
cons/weaknesses of the
method?
The only weakness of this method is that it does not cover all of the analytes outlined
in the SMPR.
7. Any general comments
about the method?
Would like to see additional work to determine if the missing analytes could be added.
Do you recommend this
method be adopted as a First
Action and published in the
Official Methods of Analysis
of AOAC INTERNATIONAL?
Please specify rationale.
Yes, if partnered with another method (TEA-01) for a more complete analysis of SMPR
requirements.