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148

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

2484-P

lat

8:30

am

FROM CHARGE STATE TO ISOSURFACES TO SPECTRA:

UNRAVELING THE MYSTERY OF LYS-TRP DIPEPTIDE

FLUORESCENCE.

Azaria Eisenberg

, Laura Juszczak

2485-P

lat

8:45

am

REAL-TIME QUANTIFICATION OF TIME-GATED

AUTOFLUORESCENCE SPECTRUM SHAPE TO TRACK

MITOCHONDRIAL METABOLISM.

Paul Urayama

, Jeff Maltas, Zac

Long, Arthur Oliva, Jeff Folz, Lana Amer, Dylan Palo

2486-P

lat

9:00

am

NANOSCALE INFRARED SPECTROSCOPY OF BIOLOGICAL

SYSTEMS.

Eoghan Dillon

, Mike Lo, Kevin Kjoller, Qichi Hu, Roshan

Shetty

2487-P

lat

9:15

am

FLAVONOLS AS LUMINESCENT PROBES OF WATER ACTIVITY

IN FOODS AND PHARMACEUTICALS. Siyu (Suzie) Wang, An N.

Le, Maria G. Corradini,

Richard D. Ludescher

2488-P

lat

9:30

am

SENSITIVE DETECTION OF NAD

+

/NADP

+

VIA STRONG

COUPLING FLUORESCENCE FROM SILVER NANOCLUSTERS.

Yufeng Yuan, Yan Chen, Kehan Huang, Haifeng Pan, Sanjun Zhang,

Jianhua Xu

2489-P

lat

9:45

am

NON-DESTRUCTIVE LABEL-FREE MONITORING OF DRUG

INTAKE IN LIVE CELLS USING ATR FT-IR SPECTROSCOPY.

Pedro L. Fale

, K. L. Andrew Chan

2490-P

lat

10:00

am

PHOTOBLEACHING CORRECTION IN FLUORESCENCE

CORRELATION SPECTROSCOPY.

Rudra P. Kafle

, Molly R.

Liebeskind, Jens-Christian Meiners

8:15

am

–10:15

am

, R

oom

307/308

Platform

Cell Mechanics, Mechanosensing, and

Motility II

Co-Chairs

Begona Alvarez-Gonzalez, University of California, San Diego

Christian Franck, Brown University

2491-P

lat

8:15

am

HIGH RESOLUTION, LARGE DEFORMATION 3D TRACTION

FORCE MICROSCOPY. Jennet Toyjanova, Eyal Bar-Kochba, Cristina

Lopez-Fagundo, Jonathan Reichner, Diane Hoffman-Kim,

Christian Franck

2492-P

lat

8:30

am

CORRELATIVE TRACTION FORCE MICROSCOPY AND

FLUORESCENCE FLUCTUATION ANALYSIS OF MOLECULAR

AGGREGATION AND COMPLEX FORMATION IN CELL

ADHESIONS IN DISTINCT MICROENVIRONMENTS.

Alexia I. Bachir

, Jessica Zareno, Kristopher E. Kubow, Sangyoon Han,

Kostadinos Moissoglu, Gaudenz Danuser, Enrico Gratton, Edward Plow,

Alan R. Horwitz

2493-P

lat

8:45

am

TRACKING ROTATION DURING LEUKOCYTE ROLLING

REVEALS ASYMMETRIC ADHESION PROPERTIES.

Isaac T.S. Li

,

Taekjip Ha, Yann R. Chemla

2494-P

lat

9:00

am

CHROMATIN ASSOCIATION WITH THE NUCLEAR ENVELOPE

SUPPORTS STABLE NUCLEAR MECHANICS.

Sarah M. Schreiner

,

Peter K. Koo, Yao Zhao, Simon G. J. Mochrie, Megan C. King

2495-P

lat

9:15

am

THREE-DIMENSIONAL BALANCE OF CORTICAL TENSION

AND AXIAL CONTRACTILITY ENABLES FAST AMOEBOID

MIGRATION.

Begona Alvarez-Gonzalez

, Ruedi Meili, Effie Bastounis,

Richard A. Firtel, Juan C. Lasheras, Juan C. del Alamo

2496-P

lat

9:30

am

MEASURING MECHANICAL FORCE DURING ZEBRAFISH

DEVELOPMENT USING AN EXPRESSIBLE TENSION SENSOR.

Andrea Hamilton

, Victoria Wu, Alex Dunn, Ingmar Riedel-Kruse

2497-P

lat

9:45

am

TWO DISTINCT REGIMES OF INTEGRIN MOLECULAR

FORCES.

Xuefeng Wang

, Taekjip Ha

2498-P

lat

10:00

am

DYNAMIC TRACTION FORCES OF HUMAN NEUTROPHIL

ADHESION.

Steven J. Henry

, Christopher S. Chen, John C. Crocker,

Daniel A. Hammer

8:15

am

–10:15

am

, R

oom

309/310

Platform

Intrinsically Disordered Proteins (IDP) and

Aggregates

Co-Chairs

Alexandra Klinger, University of Pennsylvania

Mark Brown, Yale University

2499-P

lat

8:15

am

SEQUENCE SPECIFIC RADIOLYTIC FOOTPRINTING STUDY

OF MONOMER, OLIGOMERIC AND FIBRILLAR AMYLOID

BETA (1-42).

Alexandra L. Klinger

, Janna Kiselar, Anant Paravastu,

Terrone Rosenberry

2500-P

lat

8:30

am

NOVEL METHODOLOGIES FOR THE COMPUTATIONAL

STUDY OF PROTEIN AGGREGATION.

David Shorthouse

, Thomas

Gallagher, Mark Sansom

2501-P

lat

8:45

am

MULTISCALE SIMULATIONS PROVIDE MECHANISTIC

INSIGHTS INTO THE EFFECTS OF SEQUENCE CONTEXTS ON

EARLY-STAGE POLYGLUTAMINE-MEDIATED AGGREGATION.

Kiersten M. Ruff

, Rohit V. Pappu

2502-P

lat

9:00

am

NEW INSIGHT INTO AMYLOID-

β

FIBRIL GROWTH AND ITS

INHIBITION: KINETIC NETWORK ANALYSIS OF MULTI-SCALE

MOLECULAR DYNAMICS SIMULATIONS.

Wei Han

, Klaus

Schulten

2503-P

lat

9:15

am

A ROLE FOR UNSTRUCTURED RESIDUES IN THE INDUCTION

OF MEMBRANE PORATION BY PRE-AMYLOID ASSEMBLIES

OF ISLET AMYLOID POLYPEPTIDE.

Mark A. Brown

, Elizabeth

Rhoades, Andrew D. Miranker

2504-P

lat

9:30

am

KEEPING IT DISORDERED: A NEW MECHANISM OF PROTEIN

QUALITY CONTROL?

Priya R. Banerjee

, Ashok Deniz