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151
Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
W
E
D
N
E
S
D
A
Y
2541-P
lat
1:30
pm
SERCA LOCATED IN THE JUNCTIONAL SR SHAPES CALCIUM
RELEASE IN CARDIAC MYOCYTES.
Terje R. Kolstad
, Mathis
K. Stokke, Espen Stang, Sverre H. Brorson, Louch E. William, Ole M.
Sejersted
2542-P
lat
1:45
pm
LARGE AMPLITUDE RATE-DEPENDENT MECHANICAL
ALTERNANS MAY PRECEDE ARRHYTHMOGENESIS IN
HUMAN HEART FAILURE AND ARE LINKED TO ELECTRICAL
ALTERNANS VIA ABNORMAL CALCIUM HANDLING.
Melanie Zile
, Natalia Trayanova
2543-P
lat
2:00
pm
NA
+
/H
+
EXCHANGE BLOCKERS REVEAL THE EXISTENCE OF A
SKELETAL MUSCLE CA
2+
/H
+
EXCHANGER, WHICH IS ALTERED
IN MALIGNANT HYPERTHERMIA MUSCLE CELLS.
Gaelle Robin
, Francisco Altamirano, Eric Esteve, Isaac N. Pessah, Paul D.
Allen, Jose R. Lopez
2544-P
lat
2:15
pm
CALCIUM SPARKLETS IN INTACT MAMMALIAN SKELETAL
MUSCLE FIBERS EXPRESSING THE EMBRYONIC CAV1.1 SPLICE
VARIANT. Beatrix Dienes, Nasreen Sultana, Janos Vincze, Monika
Sztretye, Peter Szentesi, Bernhard E. Flucher,
Laszlo Csernoch
2545-P
lat
2:30
pm
CALCIUM CHANNEL DYSFUNCTION IN A MUTANT MOUSE
MODEL OF MALIGNANT HYPERTHERMIA(CAV1.1 R174W).
Donald Beqollari, Christin F. Romberg, Wei Feng, Jose R. Lopez,
Manuela Lavorato, Stefano Perni, Philip M. Hopkins, Clara Franzini-
Armstrong, Isaac N. Pessah, Paul D. Allen, Kurt G. Beam,
Roger A. Bannister
2546-P
lat
2:45
pm
SPATIALLY LOCALIZED DISRUPTIONS OF VOLTAGE
ACTIVATED CALCIUM RELEASE IN MTM1-DEFICIENT
MUSCLE FIBERS. Candice Kutchukian, Karine Poulard, Anna Buj-
Bello,
Vincent Jacquemond
1:00
pm
–3:00
pm
, R
oom
309/310
Platform
Mechanosensation
Co-Chairs
Camilo Andres Aponte-Santamaria, Heidelberg Institute for Theoretical
Studies (HITS), Germany
Anthony Peng, Stanford University
2547-P
lat
1:00
pm
THE PRIMARY CILIUM IS A SELF-ADAPTABLE, INTEGRATING
NEXUS FOR MECHANICAL STIMULI AND CELL SIGNALING.
An M. Nguyen, Yuan N. Young,
Christopher R. Jacobs
2548-P
lat
1:15
pm
MECHANOSENSITIVE VON WILLEBRAND FACTOR PROTEIN-
PROTEIN INTERACTIONS REGULATE HEMOSTASIS.
Camilo A. Aponte Santamaría
, Volker Huck, Sandra Posch, Agnieszka
K. Bronowska, Sandra Grässle, Maria A. Brehm, Tobias Obser, Reinhard
Schneppenheim, Peter Hinterdorfer, Stefan W. Schneider, Carsten
Baldauf, Frauke Gräter
2549-P
lat
1:30
pm
STRUCTURAL STUDY OF A NOVEL PARTIAL CALCIUM-
FREE LINKER AND A POSITIVELY SELECTED VARIATION IN
PROTOCADHERIN-15: IMPLICATIONS FOR HEARING AND
CELL ADHESION.
Robert E. Powers
, Rachelle Gaudet, Marcos
Sotomayor
2550-P
lat
1:45
pm
CALCIUM INFLUX THROUGH TRPV1 INHIBITS PIEZO
CHANNELS VIA PHOSPHOINOSITIDE DEPLETION.
Istvan Borbiro
, Doreen Badheka, Tibor Rohacs
2551-P
lat
2:00
pm
PIEZO1 TRANSDUCES EXTRACELLULAR MATRIX
MECHANICAL CUES TO DIRECT HUMAN NEURAL STEM CELL
FATE.
Medha M. Pathak
, Jamison L. Nourse, Truc Tran, Jennifer Hwe,
Janahan Arulmoli, Dai Trang T. Le, Elena Bernardis, Lisa A. Flanagan,
Francesco Tombola
2552-P
lat
2:15
pm
MECHANOSIGNALLING OF FOCAL ADHESION KINASE.
Jing Zhou
, Camilo Aponte-Santamaria, Agnieszka Bronowska, Frauke
Gräter
2553-P
lat
2:30
pm
MODULATION OF RAT AUDITORY HAIR CELL
MECHANOTRANSDUCTION CHANNEL RESTING OPEN
PROBABILITY IMPLICATES A ROLE FOR THE LIPID BILAYER.
Anthony Peng
, Radhakrishnan Gnanasamdandam, Frederick Sachs,
Anthony Ricci
2554-P
lat
2:45
pm
PROBING THE STRUCTURE AND FUNCTION OF TMC1 IN
SENSORY HAIR CELLS USING MUTAGENESIS AND CYSTEINE
MODIFICATION.
Xiao-Ping Liu
, Bifeng Pan, Yukako Asai, Kyoto
Kurima, Andrew J. Griffith, Jeffrey R. Holt
1:00
pm
–3:00
pm
, R
oom
314/315
Platform
DNA Replication and Transcription
Co-Chairs
Enrico Gratton, University of California, Irvine
Laura Finzi, Emory University
2555-P
lat
1:00
pm
international
travel awardee
INITIATION OF ASYMMETRIC ROLLING-CIRCLE PLASMID
REPLICATION BY REPD STUDIED USING MAGNETIC
TWEEZERS.
Algirdas Toleikis
, Simone Kunzelmann, Gregory I.
Mashanov, Martin R. Webb, Justin E. Molloy
2556-P
lat
1:15
pm
MECHANISTIC STUDIES OF DNA-PROTEIN INTERACTIONS
IN BACTERIOPHAGE T4 DNA REPLICATION COMPLEXES AT
SINGLE-BASE RESOLUTION.
Davis Jose
, Lee Wonbae, Gillies P.
John, Marcus H. Andrew, Peter H. von Hippel
2557-P
lat
1:30
pm
DNA TRANSLOCATIONS IN REAL-TIME: INSIGHTS INTO
NON-HOMOLOGOUS END JOINING PATHWAY.
Andrea Candelli
, Ineke Brouwer, Gerrit Sitters, Stephanie Heerema,
Mauro Modesti, Erwin J.G. Peterman, Gijs J.L. Wuite
2558-P
lat
1:45
pm
CORRELATIVE NANOMANIPULATION AND
COLOCALIZATION OF SINGLE-MOLECULES TO STUDY
TRANSCRIPTION-COUPLED DNA REPAIR.
Evan T. Graves
,
Camille Duboc, Jun Fan, Terence Strick
2559-P
lat
2:00
pm
FUNCTIONAL IMPLICATIONS OF THE RECQ HELICASE
- TOPOISOMERASE III - SSB COMPLEX: INSIGHTS FROM
SINGLE MOLECULE MEASUREMENTS.
Maria Mills
, Yeonee Seol,
Keir Neuman