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158

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

2672-P

os

B

oard

B102

GEOMETRIC DESCRIPTION OF DYNAMIN INDUCED

MEMBRANE FISSION. Pablo Vázquez-Montejo,

Zachary McDargh

,

Markus Deserno

2673-P

os

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oard

B103

TWO PATHWAYS MEDIATE INTER-DOMAIN ALLOSTERIC

REGULATION IN PIN1.

Jingjing Guo

, Xiaodong Pang, Huan-Xiang

Zhou

2674-P

os

B

oard

B104

THE IMPACT OF PERTURBING DYNAMIC AMINO ACID

NETWORKS IN A (

β

/

α

)8 BARREL ENZYME.

Kathleen F. O’Rourke

,

Jennifer M. Axe, Nicole E. Kerstetter, David D. Boehr

2675-P

os

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oard

B105

CONFORMATIONAL EXCHANGE COUPLED TO

IONIZATION OF LYS RESIDUES BURIED IN HYDROPHOBIC

ENVIRONMENTS IN PROTEINS.

Daniel E. Richman

, Ananya

Majumdar, Bertrand Garcia-Moreno

2676-P

os

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B106

NMR INVESTIGATION OF ENERGY BARRIERS FOR

HYDROGEN-BOND BREAKAGE OF PROTEIN SIDE-CHAIN

NH3+ GROUPS.

Levani Zandarashvili

, Junji Iwahara

2677-P

os

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B107

THUMB II SITE INHIBITOR ALLOSTERICALLY SUPPRESSES

THE DYNAMICS OF HCV RNA-DEPENDENT RNA

POLYMERASE.

Daniel J. Deredge

, Kenneth Johnson, Patrick Wintrode

2678-P

os

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B108

DYSFUNCTIONAL CONFORMATIONAL DYNAMICS

OF PROTEIN KINASE A FROM R14 DELETION OF

PHOSPHOLAMBAN.

Jonggul Kim

, Larry R. Masterson, Alessandro

Cembran, Raffaello Verardi, Lei Shi, Jiali Gao, Gianluigi Veglia

2679-P

os

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B109

DYNAMICAL X-RAY SINGLE MOLECULE OBSERVATIONS

OF THE MOLECULAR RECOGNITION PROCESS IN MAJOR

HISTOCOMPATIBILITY COMPLEX MOLECULE.

Toshihiro Miyabe

, Yufuku Matsushita, Kosuke Kasadera, Yuko Kozono,

Hiroshi Sekiguchi, Keigo Ikezaki, Haruo Kozono, Yuji C. Sasaki

2680-P

os

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oard

B110

UNEXPECTED VASP-EVH1 INTERACTIONS WITH IRAK1 AND

ZYXIN: PHOSPHORYLATION AND BIVALENT BINDING.

Lucila A. Acevedo

, Alex I. Greenwood, Jeahoo Kwon, Kun P. Lu, Linda

K. Nicholson

2681-P

os

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B111

INFLUENCE OF RNA BINDING ON THE CONFORMATIONAL

DYNAMICS OF THE LASSA VIRUS NUCLEOPROTEIN.

Jason Pattis

, Eric R. May

2682-P

os

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B112

SITE-SPECIFIC CONFORMATIONAL DIVERSITY IN

CALMODULIN USING CYANYLATED CYSTEINE VIBRATIONAL

PROBES ALONG ITS BINDING INTERFACES.

Kristen L. Kelly

,

Rebecca Wai, Kanika Ramchandani, Casey Londergan

2683-P

os

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oard

B113

BACKBONE FLEXIBILITY AS A DETERMINANT OF PKA VALUES

OF BURIED IONIZABLE GROUPS IN PROTEINS.

Bertrand Garcia-Moreno

, Gabrieal Ortega, Meredith T. Peck, Aaron

Robinson, Jamie L. Schlessman

2684-P

os

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B114

REGULATION OF THE MOLECULAR BRAKE REGION IN FGFR2

KINASE.

Jerome M. Karp

, David Cowburn

2685-P

os

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oard

B115

PKA VALUES OF BURIED GROUPS IN PROTEINS ARE

SENSITIVE TO THE GLOBAL THERMODYNAMIC

STABILITY.

Jaime L. Sorenson

, Raidizon Mercedes, Jamie L.

Schlessman, Bertrand García-Moreno

2686-P

os

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B116

CRITICAL ROLE OF A GLYCINE RESIDUE IN AN ALLOSTERIC

SWITCH. Dorothy Beckett,

William Cressman

Enzymes and Protein Dynamics II

(Boards B117-B134)

2687-P

os

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B117

ZINC INHIBITS HEDGEHOG AUTO

PROCESSING:LINKING

ZINC DEFICIENCY WITH HEDGEHOG ACTIVATION.

Jian Xie

,

Timothy Owen, Ke Xia, Ajay Vikram Singh, Emiley Tou, Lingyun Li, Leo

Q. Wan, Brian Callahan, Chunyu Wang

2688-P

os

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oard

B118

PROBING FACTOR XIII SUBSTRATE SPECIFICITY

FOR FIBRINOGEN

α

C (233-425) USING MALDI-TOF

MASS SPECTROMETRY AND 2D 15N-1H HSQC NMR

SPECTROSCOPY.

Kelly Njine Mouapi

, Jacob Bell, Kerrie Smith, Helen

Philippou, Robert Ariens, Muriel Maurer

2689-P

os

B

oard

B119

LIGAND BINDING TO ANION BINDING EXOSITES

AS PROTHROMBIN IS CONVERTED TO ACTIVE

THROMBIN.

Ramya Billur

, Marina V. Malovichko, Muriel C. Maurer

2690-P

os

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oard

B120

MOLECULAR DYNAMICS STUDIES OF THE UBIQUITIN

CONJUGATION MECHANISM.

Serban Zamfir

2691-P

os

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oard

B121

PROTEOLYSIS OF ABNORMAL PRION PROTEIN WITH A

THERMOSTABLE PROTEASE FROM A HYPER-THERMOPHILIC

ARCHAEON THERMOCOCCUS KODAKARENSIS KOD1.

Yuichi Koga

, Nami Shimizu, Akikazu Sakudo, Shigenori Kanaya

2692-P

os

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oard

B122

KINETIC CHARACTERIZATION OF HUMAN LIVER

PHOSPHOFRUCTOKINASE.

Amanda Tindall

, Gregory D. Reinhart

2693-P

os

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oard

B123

USE OF 2-PHOTON FLUORESCENCE CORRELATION

SPECTROSCOPY AND ELECTRON MICROSCOPY TO

ELLUCIDATE THE DEPENDENCE OF RLPFK SELF

ASSOCIATION ON LIGAND CONCENTRATION.

David Holland

,

Jeng-Yih Chang, Junjie Zhang, Gregory D. Reinhart

2694-P

os

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oard

B124

THE ISOLATED LARGE SUBUNIT OF E. COLI

CARBAMOYLPHOSPHATE SYNTHETASE DEVIATES FROM

KINETIC MECHANISM AND ALLOSTERIC BEHAVIOR OF THE

HOLOENZYME.

Robert Koenig

, Gregory D. Reinhart

2695-P

os

B

oard

B125

FREE-ENERGY LANDSCAPES OF THE TRANSLOCATION

OF A SUBSTRATE IN FOUR PROTEASOME - ACTIVATOR

COMPLEXES ANALYZED USING MOLECULAR DYNAMICS

SIMULATIONS.

Hisashi Ishida