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162

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

Membrane Active Peptides and Toxins II

(Boards B201-B227)

2771-P

os

B

oard

B201

THE PRESENCE OF ANTIPARALLEL BETA-SHEETS IN TOXIC

FIBRILS FORMED BY ABETA ON GM1 CLUSTERS. Yuki Okada,

Hiroshi Ueno, Yoshiaki Yano, Masaru Hoshino, Hikari Itoh-Watanabe,

Akira Naito,

Katsumi Matsuzaki

2772-P

os

B

oard

B202

STRUCTURAL TRANSFORMATION OF AMYLOID PEPTIDES

INTERACTING WITH LIPID MEMBRANES. Yen Sun,

Huey W. Huang

2773-P

os

B

oard

B203

ALPHA-SYNUCLEIN STABILIZES SMALL UNILAMELLAR

VESICLES BY REDUCING BOTH MEMBRANE SURFACE

TENSION AND RIGIDITY.

Anthony R. Braun

, Jonathan N. Sachs

2774-P

os

B

oard

B204

MEMBRANES CAN FINELY TUNE PEPTIDE-INDUCED

LIPID EXTRACTION BY MODULATING THEIR LIPID

COMPOSITION. Alexandre Therrien,

Michel Lafleur

2775-P

os

B

oard

B205

MECHANISM OF ACTION OF

β

-HAIRPIN ANTIMICROBIAL

PEPTIDES.

Richard B. Lipkin

, Themis Lazaridis

2776-P

os

B

oard

B206

ATTACK ON SINGLE ESCHERICHIA COLI SPHEROPLASTS BY

ANTIMICROBIAL PEPTIDES.

Tzu-Lin Sun

, Yen Sun, Huey W. Huang

2777-P

os

B

oard

B207

INSIGHTS INTO THE EFFECTS OF ANTIMICROBIAL PEPTIDES

ON LIVE E. COLI CELLS USING TIME-LAPSE FLUORESCENCE

MICROSCOPY.

Ranga Rajan

, James C. Weisshaar

2778-P

os

B

oard

B208

HISTIDINE-RICH DESIGNER PEPTIDES WITH PH-

DEPENDENT MEMBRANE TOPOLOGY, ANTIMICROBIAL,

NUCLEIC ACID TRANSFECTION AND VIRAL TRANSDUCTION

CAPABILITIES. Christopher Aisenbrey, Philippe Bertani, Andrea

Farrotti, David Fenard, Anne Galy, Elise Glattard, Arnaud Marquette,

Jesus Raya, Evgeniy S. Salnikov, Joachim Seelig, Lorenzo Stella, Louic

Vermeer, Nathaliia Voievoda,

Burkhard Bechinger

2779-P

os

B

oard

B209

EFFECT OF HISTIDINE RICH ANTIMICROBIAL

PEPTIDES,GAD-1 AND GAD-2,ON MODEL MEMBRANES

AT DIFFERENT PH VALUES.

Gagandeep K. Sandhu

, Michael R.

Morrow, Valerie Booth

2780-P

os

B

oard

B210

THE TRANSMEMBRANE STATE OF ANTIMICROBIAL PISCIDIN

IN BACTERIAL CELL MEMBRANE MIMICS DRAMATICALLY

ALTERS THE POLAR-NONPOLAR SEGREGATION OF THE

BILAYER.

Myriam Cotten

, Jorge I. Hernandez, Kimberly Bogardus,

Mihaela Mihailescu

2781-P

os

B

oard

B211

ANTIMICROBIAL PEPTIDE PISCIDIN PERMEABILIZES

BACTERIAL MEMBRANES AND BINDS INTRACELLULAR

TARGETS AT SUB-LETHAL CONCENTRATIONS.

Mason Schoeneck

, Robert Hayden, Gina Goldberg, Bryan Ferguson,

Michael McCormick, Herman Lehman, Myriam Cotten

2782-P

os

B

oard

B212

MOLECULAR DYNAMICS SIMULATIONS REVEAL

MECHANISTIC DETAILS OF POLYMYXIN PENETRATION INTO

BOTH MEMBRANES OF E.COLI.

Syma Khalid

, Nils A. Berglund,

Peter J. Bond, Thomas J. Piggot

2783-P

os

B

oard

B213

THERMODYNAMICS GOVERN THE MECHANISM OF

ANTIMICROBIAL LIPOPEPTIDES: INSIGHTS FROM COARSE-

GRAINED MOLECULAR DYNAMICS SIMULATIONS.

Dejun Lin

,

Alan Grossfield

2784-P

os

B

oard

B214

THE NATURE OF DAPTOMYCIN AGGREGATES.

Ming-Tao Lee

,

Wei-Chin Hung, Yen-Fei Chen, Huey W. Huang

2785-P

os

B

oard

B215

LIPID SELECTIVITY OF FUNGICIDAL LIPOPEPTIDES.

Sebastian Fiedler

, Quang Huynh, Hiren Patel, Heiko Heerklotz

2786-P

os

B

oard

B216

STRUCTURE AND MEMBRANE TOPOLOGY OF THE PORE-

FORMING PEPTIDE MACULATIN 1.1.

Marc-Antoine Sani

, Terry P.

Lybrand, Frances Separovic

2787-P

os

B

oard

B217

STRUCTURE OF TRANSMEMBRANE PORES STABILIZED BY

ANTIMICROBIAL PEPTIDES MAGAININ AND PGLA.

Almudena Pino Angeles

, John M. Leveritt III, Themis Lazaridis

2788-P

os

B

oard

B218

MODULATION OF THE INTERACTION BETWEEN

DETERGENT MICELLES AND MODEL PEPTIDE ANTIBIOTICS

BY VARYING THE PEPTIDE CHARGE DISTRIBUTION.

John Weirich

, Brianna Haight, Olivier Lequin, Lucie Khemtémourian,

Ludovic Carlier, Adrienne Loh

2789-P

os

B

oard

B219

ISOMERIC MODEL ANTIBIOTIC PEPTIDES DIFFERING ONLY

IN CHARGE PLACEMENT ADOPT DIFFERENT HELICAL

CONFORMATIONS. Jayna Sharma, Riley Larson, Olivier Lequin,

Lucie Khemtémourian, Ludovic Carlier, Kevin Larsen, Theodore Savage,

Adrienne Loh

2790-P

os

B

oard

B220

ANISOTROPIC MEMBRANE CURVATURE SENSING BY

ANTIBACTERIAL PEPTIDES. Jordi Gómez-Llobregat,

Martin Lindén

2791-P

os

B

oard

B221

MEMBRANE INTERACTION OF AN ANTI-BACTERIAL

AAPEPTIDE DEFINED BY EPR SPECTROSCOPY.

Pavanjeet Kaur

,

Yaqiong Li, Jianfeng Cai, Likai Song

2792-P

os

B

oard

B222

ACTIVITY OF ANTIMICROBIAL PEPTIDE PROTEGRIN-1 IS

TUNED BY MEMBRANE CHOLESTEROL CONTENT.

J. Michael Henderson

, Kathleen D. Cao, Zhiliang L. Gong, Gregory T.

Tietjen, Charles T. R. Heffern, Daniel Kerr, Nishanth Iyengar, Indroneil

Roy, Alan J. Waring, Mati Meron, Binhua Lin, Sushil Satija, Jaroslaw

Majewski, Ka Yee C. Lee

2793-P

os

B

oard

B223

WHAT VESICLE LEAKAGE REVEALS ABOUT ANTIMICROBIAL

ACTIVITY (AND WHAT IT DOESN’T). Sara Hovakeemian, Runhui

Liu, Samuel H. Gellman,

Heiko Heerklotz