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166

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

2864-P

os

B

oard

B294

STIM1 AND STIM2 PROTEINS REGULATION OF

ENDOGENOUS STORE-OPERATED CALCIUM CHANNELS IN

HEK293 CELLS.

Alexey Shalygin

, Olga Zimina, Vera Kamaletdinova,

Anton Skopin, Lyuba Glushankova, Galina N. Mozhayeva, Elena

Kaznacheyeva

2865-P

os

B

oard

B295

STIM1-STIM2 INTERACTIONS MODULATE STORE-OPERATED

CALCIUM ENTRY.

Krishna Subedi

, Hwei Ling Ong, Indu Ambudkar

2866-P

os

B

oard

B296

REMODELING OF THE CYTOSKELETON AND REGULATION

OF STORE-OPERATED CALCIUM ENTRY.

Lorena de Souza

,

Timothy Lockwich, Hwei Ling Ong, Kwong Tai Cheng, Indu S.

Ambudkar

2867-P

os

B

oard

B297

A NOVEL STIM2 SPLICE VARIANT FUNCTIONS AS A BREAK

FOR STIM MEDIATED ACTIVATION OF ORAI CALCIUM

CHANNELS.

Anna-Maria Miederer

, Dalia Alansary, Gertrud Schwaer,

Martin Jung, Barbara A. Niemeyer

2868-P

os

B

oard

B298

ROLES OF THE ORAI1 C-TERMINUS AND N-TERMINUS IN

2-APB-INDUCED STIM1 COUPLING.

Yandong Zhou

, Youjun Wang,

Xizhuo Wang, Natalia A. Loktionova, Xianming Wang, Donald L. Gill

2869-P

os

B

oard

B299

international

travel awardee

MENTHOL-INDUCED CHANGES IN MESENCHYMAL STEM

CELL DIFFERENTIATION. Juan C. Henao, Adriana Grismaldo,

Yolima P. Torres

Intracellular Calcium Channels and

Calcium Sparks and Waves II

(Boards B300-B316)

2870-P

os

B

oard

B300

MICU1 AND MICU2 OPERATE TOGETHER TO REGULATE THE

UNIPORTER.

Kimberli J. Kamer

, Vamsi K. Mootha

2871-P

os

B

oard

B301

ACTIVATION OF MITOCHONDRIAL SK CHANNELS IN

CARDIOMYOCYTES DERIVED FROM HYPERTROPHIC

HEARTS ATTENUATES CCA

2+

-DEPENDENT ARRHYTHMIA BY

REDUCING MITOCHONDRIAL ROS PRODUCTION THEREBY

STABILIZING RYRS. TaeYun Kim, Weiyan Li, Karim Roder, Radmila

Terentyeva, Gideon Koren, Bum-Rak Choi,

Dmitry Terentyev

2872-P

os

B

oard

B302

ALTERED RYANODINE RECEPTOR FUNCTION IN

ISCHEMIC HEART DISEASE: IS THERE A ROLE FOR

MITOCHONDRIA?

Demetrio J. Santiago

, Eef Dries, Ilse Lenaerts,

Karin R. Sipido

2873-P

os

B

oard

B303

STATIN INDUCED MYOPATHY: A ROLE FOR

MITOCHONDRIAL CA

2+

AND NO IN ENHANCED

SARCOPLASMIC RETICULUM CA

2+

LEAK.

Sabine Lotteau

, David

MacDougall, Derek Steele, Sarah Calaghan

2874-P

os

B

oard

B304

RIESKE IRON-SULFUR PROTEIN-DEPENDENT

MITOCHONDRIAL ROS-MEDIATED DISSOCIATION OF

FKBP12.6/RYR2 COMPLEX PLAYS AN ESSENTIAL ROLE IN

PULMONARY HYPERTENSION.

Yong-Xiao Wang

, Yun-Min Zheng

2875-P

os

B

oard

B305

CALCIUM SIGNALING AMONG RYR2S WITHIN A CALCIUM

RELEASE UNIT DURING A CALCIUM SPARK.

Didier X.P. Brochet

,

Gang Wang, W. Jonathan Lederer, Heping Cheng

2876-P

os

B

oard

B306

BIOORTHOGONAL CALCIUM MODULATION BY DIRECT

INTRACELLULAR ACCESS USING NANOSTRAWS.

Alexander Xu

,

Amin Aalipour, Sally Kim, Nicholas Melosh

2877-P

os

B

oard

B307

EFFECTS OF ARRHYTHMOGENIC MUTATIONS ON CA

2+

-

INDUCED CA

2+

RELEASE ACTIVITIES OF TYPE 2 RYANODINE

RECEPTORS.

Nagomi Kurebayashi

, Takashi Murayama, Junji Suzuki,

Kazunori Kanemaru, Masamitsu Iino, Takashi Sakurai

2878-P

os

B

oard

B308

DHBP BLOCK OF RYANODINE RECEPTOR

CHANNELS.

Yuanzhao Lv

, Julio A. Copello

2879-P

os

B

oard

B309

FILLING THE GAP BETWEEN CALCIUM SPARKS AND

WAVES: AUTOMATIC DETECTION AND CLASSIFICATION

OF LOCAL CALCIUM RELEASES IN CARDIAC PACEMAKER

CELLS.

Alexander V. Maltsev

, Michael D. Stern

2880-P

os

B

oard

B310

BASAL ACTIVITY OF EPIDERMAL GROWTH FACTOR

RECEPTOR (EGFR) AND PHOSPHOLIPASE C (PLC) ARE

REQUIRED TO SUSTAIN SPONTANEOUS BEATING OF

CARDIAC PACEMAKER CELLS.

Tatiana M. Vinogradova

, Kirill V.

Tarasov, Edward G. Lakatta

2881-P

os

B

oard

B311

A NEW SIMPLIFIED 3D MODEL OF CARDIAC PACEMAKER

CELL BASED ON SUPERRESOLUTION STRUCTURED

ILLUMINATION MICROSCOPY (SIM).

Victor A. Maltsev

, Oliver

Monfredi, Hari Shroff, Andrew G. York, Anna V. Maltsev, Edward G.

Lakatta, Michael D. Stern

2882-P

os

B

oard

B312

GLYCOSIDE-INDUCED COLLAPSE OF THE SODIUM AND

CALCIUM GRADIENTS LEADS TO A BIPHASIC EFFECT ON

CARDIAC CELL PACEMAKER FUNCTION.

Rostislav Bychkov

,

Syevda Sirenko, Yael Yaniv, Victor A. Maltsev, Edward G. Lakatta

2883-P

os

B

oard

B313

AUTONOMIC STIMULATION MODULATES ACTION

POTENTIAL FIRING RATE IN CARDIAC PACEMAKER CELLS

VIA SYNCHRONIZATION OF LOCAL CALCIUM PUMPING AND

RELEASE.

Oliver J. Monfredi

, Edward G. Lakatta, Victor A. Maltsev

2884-P

os

B

oard

B314

EXCITATION-METABOLISM COUPLING IN MOUSE

HEART.

Andrew P. Wescott

, W. J. Lederer, George S. B. Williams

2885-P

os

B

oard

B315

SIMILARITIES AND DIFFERENCES IN GATING OF THE TWO-

PORE CHANNELS TPC1 AND TPC2.

Archana Jha

, Malini Ahuja,

Shmuel Muallem

2886-P

os

B

oard

B316

MITOCHONDRIAL CALCIUM AND BIOENERGETICS

CONTROLLED BY TIGHT COORDINATION OF MCU AND

NCLX.

Ming-Feng Tsai

, Chuck Phillips, Christopher Miller