167
Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
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Nucleo-Cytoplasmic Transport
(Boards B317-B322)
2887-P
os
B
oard
B317
OBSERVING SIGNAL TRANSDUCTION DIRECTLY AT THE
SINGLE-MOLECULE LEVEL IN LIVE EUKARYOTIC CELLS.
Adam JMWollman
, Sviatlana Shashkova, Erik Hedlund, Stefan
Hohmann, Mark C. Leake
2888-P
os
B
oard
B318
IN VIVO ANALYSIS OF PROTEIN CROWDING IN THE
NUCLEAR PORE COMPLEX DURING INTERPHASE AND
MITOSIS.
Hide A Konishi
, Suguru Asai, Tomonobu M Watanabe, Shige
H Yoshimura
2889-P
os
B
oard
B319
MICROINJECTION OF FL-TRNA FOR THE STUDY OF TRNA
SUBCELLULAR DYNAMICS.
Sean E. Anderson
, Anna Kashina, Haim
H. Bau, Barry S. Cooperman
2890-P
os
B
oard
B320
INVOLVEMENT OF WATER MOLECULES IN THE FORMATION
OF HYDROPHOBIC BARRIER IN THE NUCLEAR PORE
COMPLEX.
Suguru Asai
, Hide A. Konishi, Shige H. Yoshimura
2891-P
os
B
oard
B321
MONITORING AND MODELING EFFECTS OF IGF1, INSULIN
AND GREEN TEA COMPOUND EGCG ON NUCLEAR-
CYTOPLASMIC DISTRIBUTION OF FOXO1-GFP IN SKELETAL
MUSCLE FIBERS. Robert Wimmer,
Sarah Russell
, Bradford Peercy,
Martin Schneider
2892-P
os
B
oard
B322
THE AUTOPHAGOSOME MARKER LC3 UNDERGOES
REGULATED TARGETING TO THE NUCLEUS AND
NUCLEOLUS.
Lewis J. Kraft
, Jacob Dowler, Anne K. Kenworthy
Voltage-gated Na Channels
(Boards B323-B350)
2893-P
os
B
oard
B323
RESTING STATE OF S4 IDENTIFIED FOR EACH DOMAIN OF
NAV1.2 USING OMEGA CURRENT TECHNIQUE.
Claudia Lehmann
, Hansjakob Heldstab, Nikolaus G. Greeff
2894-P
os
B
oard
B324
SELECTIVE IMMOBILIZATION OF S4 IN DOMAIN III
AND IV OF RAT BRAIN NAV1.2 SHOWN BY OMEGA
CURRENTS.
Nikolaus Greeff
, Hansjakob Heldstab, Claudia Lehmann
2895-P
os
B
oard
B325
VOLTAGE SENSOR DOMAINS AND CLOSED-STATE
INACTIVATION IN SODIUM CHANNELS.
James R. Groome
2896-P
os
B
oard
B326
GATING PORE CURRENTS ARE COMMON DEFECTS OF
TWO NAV1.5 MUTATIONS IN PATIENTS WITH MIXED
ARRHYTHMIAS AND DILATED CARDIOMYOPATHY.
Adrien Moreau
, Pascal Gosselin-Badaroudine, Lucie Delemotte, Michael
L. Klein, Mohamed Chahine
2897-P
os
B
oard
B327
INTERACTION OF THE CARDIAC SODIUM CHANNEL ALPHA-
SUBUNITS LEADS TO COUPLED GATING PROPERTIES.
Jérôme Clatot
, Haiyan Liu, Eckard Ficker, Isabelle Deschênes
2898-P
os
B
oard
B328
SUPERRESOLUTION MICROSCOPY REVEALS SODIUM
CHANNEL LOCALIZATION WITHIN INTERCALATED
DISK MICRODOMAINS: IMPLICATIONS FOR EPHAPTIC
COUPLING.
Rengasayee Veeraraghavan
, Joyce Lin, James P. Keener,
Steven Poelzing, Robert G. Gourdie
2899-P
os
B
oard
B329
LOSS OF CALMODULIN-MEDIATED REGULATION OF
NA
+
CHANNEL CAUSES REMODELING OF ELECTRICAL
AND JUNCTIONAL PROTEINS; AND INDUCES DILATED
CARDIOMYOPATHY IN IQ/AA
+/-
MICE.
Rosy Joshi-Mukherjee
,
Hana Cho, Takeshi Aiba, Deborah DiSilvestre, Gordon F. Tomaselli
2900-P
os
B
oard
B330
MUTATION SPECIFIC DRUG RESPONSE AND CARDIAC RISK
IN LONG QT TYPE 3.
Elsa Ronzier
, Yitschak Biton, Alessandra
Matavel, Arthur Moss, Wojciech Zareba, Coeli Lopes
2901-P
os
B
oard
B331
ROTATIONAL SYMMETRY OF TWO PYRETHROID RECEPTOR
SITES IN THE MOSQUITO SODIUM CHANNEL. Yuzhe Du,
Yoshiko Nomura, Ke Dong,
Boris S. Zhorov
2902-P
os
B
oard
B332
NAV1.7 INHIBITOR, PF-05089771, INHIBITS FAST- AND
SLOW-INACTIVATED CHANNELS WITH SIMILAR
AFFINITIES.
Jonathan Theile
, Matthew Fuller, Mark Chapman
2903-P
os
B
oard
B333
STRUCTURAL MODELING OF LOCAL ANESTHETIC BINDING
TO THE PORE-DOMAIN OF HUMAN NAV1.5 IN OPEN AND
CLOSED STATES USING ROSETTA.
Kevin DeMarco
2904-P
os
B
oard
B334
UNDERSTANDING THE STATE DEPENDENCE OF VOLTAGE
SENSOR TOXIN ACTION ON VOLTAGE GATED SODIUM
CHANNELS.
Phuong T. Nguyen
, Ian H. Kimball, Kenneth S. Eum,
Bruce E. Cohen, Jon T. Sack, Vladimir Yarov-Yarovoy
2905-P
os
B
oard
B335
TARGETING
PROTEIN:PROTEININTERACTION SITES FOR
DRUG DEVELOPMENT AGAINST VOLTAGE-GATED SODIUM
CHANNELS.
Syed R. Ali
, Zhiqing Liu, Miroslav N. Nenov, Neli I.
Panova-Elektro, Jia Zhou, Svetla Stoilova-McPhie, Fernanda Laezza
2906-P
os
B
oard
B336
SODIUM SELECTIVE CONDUCTION, INACTIVATION
AND INHIBITION MECHANISMS USING THE BACTERIAL
NAVAB CHANNEL. Céline Boiteux, Igor Vorobyov, Robert J. French,
Christopher French, Vladimir Yarov-Yarovoy,
Toby W. Allen
2907-P
os
B
oard
B337
MOLECULAR DYNAMICS SIMULATIONS DESCRIBE
THE MECHANISM OF K BLOCK IN BACTERIAL NAV
CHANNELS. Van Ngo, Yibo Wang, Sergei Noskov, Stephan Haas,
Robert A. Farley
2908-P
os
B
oard
B338
MOLECULAR DYNAMICS STUDY OF ION CONDUCTION AND
SELECTIVITY IN A PROKARYOTIC ION CHANNEL.
Karen M. Callahan
, Benoît Roux
2909-P
os
B
oard
B339
COUPLING OF CHANNEL FLUCTUATIONS IN ION
PERMEATION AND SELECTIVITY IN BACTERIAL SODIUM
CHANNEL NAVAB.
Christopher Ing
, Nilmadhab Chakrabarti, Ning
Zheng, William A. Catterall, Régis Pomès