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167

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

W

E

D

N

E

S

D

A

Y

Nucleo-Cytoplasmic Transport

(Boards B317-B322)

2887-P

os

B

oard

B317

OBSERVING SIGNAL TRANSDUCTION DIRECTLY AT THE

SINGLE-MOLECULE LEVEL IN LIVE EUKARYOTIC CELLS.

Adam JMWollman

, Sviatlana Shashkova, Erik Hedlund, Stefan

Hohmann, Mark C. Leake

2888-P

os

B

oard

B318

IN VIVO ANALYSIS OF PROTEIN CROWDING IN THE

NUCLEAR PORE COMPLEX DURING INTERPHASE AND

MITOSIS.

Hide A Konishi

, Suguru Asai, Tomonobu M Watanabe, Shige

H Yoshimura

2889-P

os

B

oard

B319

MICROINJECTION OF FL-TRNA FOR THE STUDY OF TRNA

SUBCELLULAR DYNAMICS.

Sean E. Anderson

, Anna Kashina, Haim

H. Bau, Barry S. Cooperman

2890-P

os

B

oard

B320

INVOLVEMENT OF WATER MOLECULES IN THE FORMATION

OF HYDROPHOBIC BARRIER IN THE NUCLEAR PORE

COMPLEX.

Suguru Asai

, Hide A. Konishi, Shige H. Yoshimura

2891-P

os

B

oard

B321

MONITORING AND MODELING EFFECTS OF IGF1, INSULIN

AND GREEN TEA COMPOUND EGCG ON NUCLEAR-

CYTOPLASMIC DISTRIBUTION OF FOXO1-GFP IN SKELETAL

MUSCLE FIBERS. Robert Wimmer,

Sarah Russell

, Bradford Peercy,

Martin Schneider

2892-P

os

B

oard

B322

THE AUTOPHAGOSOME MARKER LC3 UNDERGOES

REGULATED TARGETING TO THE NUCLEUS AND

NUCLEOLUS.

Lewis J. Kraft

, Jacob Dowler, Anne K. Kenworthy

Voltage-gated Na Channels

(Boards B323-B350)

2893-P

os

B

oard

B323

RESTING STATE OF S4 IDENTIFIED FOR EACH DOMAIN OF

NAV1.2 USING OMEGA CURRENT TECHNIQUE.

Claudia Lehmann

, Hansjakob Heldstab, Nikolaus G. Greeff

2894-P

os

B

oard

B324

SELECTIVE IMMOBILIZATION OF S4 IN DOMAIN III

AND IV OF RAT BRAIN NAV1.2 SHOWN BY OMEGA

CURRENTS.

Nikolaus Greeff

, Hansjakob Heldstab, Claudia Lehmann

2895-P

os

B

oard

B325

VOLTAGE SENSOR DOMAINS AND CLOSED-STATE

INACTIVATION IN SODIUM CHANNELS.

James R. Groome

2896-P

os

B

oard

B326

GATING PORE CURRENTS ARE COMMON DEFECTS OF

TWO NAV1.5 MUTATIONS IN PATIENTS WITH MIXED

ARRHYTHMIAS AND DILATED CARDIOMYOPATHY.

Adrien Moreau

, Pascal Gosselin-Badaroudine, Lucie Delemotte, Michael

L. Klein, Mohamed Chahine

2897-P

os

B

oard

B327

INTERACTION OF THE CARDIAC SODIUM CHANNEL ALPHA-

SUBUNITS LEADS TO COUPLED GATING PROPERTIES.

Jérôme Clatot

, Haiyan Liu, Eckard Ficker, Isabelle Deschênes

2898-P

os

B

oard

B328

SUPERRESOLUTION MICROSCOPY REVEALS SODIUM

CHANNEL LOCALIZATION WITHIN INTERCALATED

DISK MICRODOMAINS: IMPLICATIONS FOR EPHAPTIC

COUPLING.

Rengasayee Veeraraghavan

, Joyce Lin, James P. Keener,

Steven Poelzing, Robert G. Gourdie

2899-P

os

B

oard

B329

LOSS OF CALMODULIN-MEDIATED REGULATION OF

NA

+

CHANNEL CAUSES REMODELING OF ELECTRICAL

AND JUNCTIONAL PROTEINS; AND INDUCES DILATED

CARDIOMYOPATHY IN IQ/AA

+/-

MICE.

Rosy Joshi-Mukherjee

,

Hana Cho, Takeshi Aiba, Deborah DiSilvestre, Gordon F. Tomaselli

2900-P

os

B

oard

B330

MUTATION SPECIFIC DRUG RESPONSE AND CARDIAC RISK

IN LONG QT TYPE 3.

Elsa Ronzier

, Yitschak Biton, Alessandra

Matavel, Arthur Moss, Wojciech Zareba, Coeli Lopes

2901-P

os

B

oard

B331

ROTATIONAL SYMMETRY OF TWO PYRETHROID RECEPTOR

SITES IN THE MOSQUITO SODIUM CHANNEL. Yuzhe Du,

Yoshiko Nomura, Ke Dong,

Boris S. Zhorov

2902-P

os

B

oard

B332

NAV1.7 INHIBITOR, PF-05089771, INHIBITS FAST- AND

SLOW-INACTIVATED CHANNELS WITH SIMILAR

AFFINITIES.

Jonathan Theile

, Matthew Fuller, Mark Chapman

2903-P

os

B

oard

B333

STRUCTURAL MODELING OF LOCAL ANESTHETIC BINDING

TO THE PORE-DOMAIN OF HUMAN NAV1.5 IN OPEN AND

CLOSED STATES USING ROSETTA.

Kevin DeMarco

2904-P

os

B

oard

B334

UNDERSTANDING THE STATE DEPENDENCE OF VOLTAGE

SENSOR TOXIN ACTION ON VOLTAGE GATED SODIUM

CHANNELS.

Phuong T. Nguyen

, Ian H. Kimball, Kenneth S. Eum,

Bruce E. Cohen, Jon T. Sack, Vladimir Yarov-Yarovoy

2905-P

os

B

oard

B335

TARGETING

PROTEIN:PROTEIN

INTERACTION SITES FOR

DRUG DEVELOPMENT AGAINST VOLTAGE-GATED SODIUM

CHANNELS.

Syed R. Ali

, Zhiqing Liu, Miroslav N. Nenov, Neli I.

Panova-Elektro, Jia Zhou, Svetla Stoilova-McPhie, Fernanda Laezza

2906-P

os

B

oard

B336

SODIUM SELECTIVE CONDUCTION, INACTIVATION

AND INHIBITION MECHANISMS USING THE BACTERIAL

NAVAB CHANNEL. Céline Boiteux, Igor Vorobyov, Robert J. French,

Christopher French, Vladimir Yarov-Yarovoy,

Toby W. Allen

2907-P

os

B

oard

B337

MOLECULAR DYNAMICS SIMULATIONS DESCRIBE

THE MECHANISM OF K BLOCK IN BACTERIAL NAV

CHANNELS. Van Ngo, Yibo Wang, Sergei Noskov, Stephan Haas,

Robert A. Farley

2908-P

os

B

oard

B338

MOLECULAR DYNAMICS STUDY OF ION CONDUCTION AND

SELECTIVITY IN A PROKARYOTIC ION CHANNEL.

Karen M. Callahan

, Benoît Roux

2909-P

os

B

oard

B339

COUPLING OF CHANNEL FLUCTUATIONS IN ION

PERMEATION AND SELECTIVITY IN BACTERIAL SODIUM

CHANNEL NAVAB.

Christopher Ing

, Nilmadhab Chakrabarti, Ning

Zheng, William A. Catterall, Régis Pomès