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168

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

2910-P

os

B

oard

B340

EXPRESSION, PURIFICATION, AND PRELIMINARY

CHARACTERIZATION OF A HUMAN CARDIAC SODIUM

CHANNEL VOLTAGE SENSING DOMAIN.

Mohammed H. Bhuiyan

, Sebastien F. Poget

2911-P

os

B

oard

B341

A THERMODYNAMIC ANALYSIS OF DISEASE-CAUSING

MUTATIONS IN THE NAV1.5 C-TERMINUS. Ching-Chieh Tung,

Ricardo E. Rivera-Acevedo,

Bernd R. Gardill

, Filip Van Petegem

2912-P

os

B

oard

B342

FUNCTIONAL CONSEQUENCES OF A NOVEL NAV1.9

MUTATION (L1302F) CAUSING CONGENITAL INSENSITIVITY

TO PAIN.

Carlos G. Vanoye

, Tatiana V. Abranova, Chris C. Ramdoski,

Paul Goldberg, Charles J. Cohen, Alfred L. George

2913-P

os

B

oard

B343

INFANT SUDDEN DEATH: NOVEL MUTATIONS RESPONSIBLE

FOR IMPAIRED NAV1.5 CHANNEL FUNCTION. Jace Morganstein,

Kundan Jana, Monique N. Foster, Tomoe Y. Nakamura, Thomas V.

McDonald, Yingying Tang,

William A. Coetzee

2914-P

os

B

oard

B344

BIOPHYSICAL AND MOLECULAR ANALYSIS OF THE SODIUM

CURRENT IN HUMAN INDUCED PLURIPOTENT STEM

CELL-DERIVED CARDIOMYOCYTES. Brian K. Panama, Robert

J. Goodrow, Serge Sicouri, Charles Antzelevitch, Jacqueline A. Treat,

Jonathan M. Cordeiro

2915-P

os

B

oard

B345

NAV1.5 C-TERMINAL DOMAINS INFLUENCE CALCIUM

REGULATION OF FAST INACTIVATION SEPARATELY FROM

CALMODULIN INTERACTION.

Franck Potet

, Svetlana Stepanovic,

Sabina Kupershmidt, Alfred L. George, Jr

2916-P

os

B

oard

B346

CAMKII-DEPENDENT REGULATION OF CARDIAC SODIUM

CHANNEL.

Federica Farinelli

, Deborah DiSilvestre, Peihong Dong,

Yanli Tian, Gordon Tomaselli

2917-P

os

B

oard

B347

RECRUITMENT OF CALMODULIN TO THE TAIL OF THE

VOLTAGE-GATED SODIUM CHANNEL NAV1.2.

Liam Hovey

,

Corinne Andresen, Dagan Marx, Madeline Shea

2918-P

os

B

oard

B348

COUPLING COMPARTMENTAL MODELS TO LIVE NEURONS

TO INVESTIGATE ACTION POTENTIAL MECHANISMS.

Marco A. Navarro

, Sarah L. Debs, Lorin S. Milescu

2919-P

os

B

oard

B349

OPTIMIZING A NAV1.5 MARKOV-MODEL WITH A GENETIC

ALGORITHM.

Zach R. Teed

, Arie Krumholtz, Jonathon R. Silva

2920-P

os

B

oard

B350

RATE CONSTANT MODELS CANNOT DESCRIBE MOVEMENT

OF CHARGED ATOMS OR MOLECULES.

Bob Eisenberg

Voltage-gated Ca Channels

(Boards B351-B370)

2921-P

os

B

oard

B351

TARGETING T-TYPE CHANNELS WITH PROTXII-LIKE

TOXINS.

Autoosa Salari

, Mirela Milescu

2922-P

os

B

oard

B352

ENGINEERING SELECTIVITY IN RGK PROTEIN INHIBITION

OF CAV1/CAV2 CHANNELS.

Akil Puckerin

2923-P

os

B

oard

B353

international

travel awardee

VENTRICULAR L-TYPE CA

2+

CHANNELS AND EXPRESSION

OF RGK PROTEINS IN MOUSE MODELS ASSOCIATED WITH

DIABETES.

Jessica Köth

, Christian Fabisch, Stefan Herzig, Jan Matthes

2924-P

os

B

oard

B354

INHIBITION OF HUMAN CA

V

2.3 CHANNELS VIA μ-,

δ

- AND

κ

-OPIOID RECEPTOR ACTIVATION. Geza Berecki, Leonid Motin,

David J. Adams

2925-P

os

B

oard

B355

CONTROL OF FUNCTIONAL TARGETING OF CAV1.2

CHANNELS BY THE

Γ

6.

Roman Shirokov

, Thomas Comollo, Rose

Rendon

2926-P

os

B

oard

B356

L-TYPE CA

2+

CHANNEL CAVB SUBUNITS ASSOCIATE WITH

AND DIFFERENTIALLY REGULATE THE CARDIAC CAV3.2

T-TYPE CA

2+

CHANNEL CURRENTS.

Marites T. Woon

, Ravi C.

Balijepalli

2927-P

os

B

oard

B357

HOMOLOGOUS SERINE/THREONINE IN THE CA

V

2.2

α

1

AND

2.3

α

1

SUBUNITS BEHAVE SIMILARLY, AS STIMULATORY AND

INHIBITORY PKC SITES.

Ganesan L. Kamatchi

2928-P

os

B

oard

B358

NOREPINEPHRINE UPREGULATES T-TYPE CALCIUM

CHANNELS IN RAT PINEALOCYTES.

Haijie Yu

, Jong Bae Seo,

Seung-Ryoung Jung, Duk-Su Koh, Bertil Hille

2929-P

os

B

oard

B359

SINGLE-CHANNEL ANALYSIS OF THE INHIBITION OF THE

CALCIUM DEPENDENT INACTIVATION BY THE C-TERMINAL

MODULATOR DOMAIN OF CAV1.3 CHANNELS.

Elza

Kuzmenkina

, Elena Novikova, Wanchana Jangsangthong, Stefan Herzig

2930-P

os

B

oard

B360

SERUM FACTOR ALTERS T-TYPE CAV3.2 GATING KINETICS

AND CURRENT DENSITY.

Gray Evans

, Slobodan M. Todorovic

2931-P

os

B

oard

B361

CONVERGENT MODULATIONS BY CARBOXYL-TERMINI

ACROSS L-TYPE CALCIUM CHANNEL SUBTYPES.

Yaxiong Yang

,

Min Liu, Nan Liu, Xiaodong Liu

2932-P

os

B

oard

B362

MODAL BIFURCATION OF CAV1.3 SIGNALING IN CORTICAL

NEURONS.

Min Liu

, Yaxiong Yang, Nan Liu, Ji Tang, Xuyang Sun,

Xiaodong Liu

2933-P

os

B

oard

B363

THE EFFECT OF AUTISM CANDIDATE-GENE MUTATIONS IN

THE VOLTAGE-GATED CALCIUM CHANNEL

β

2 SUBUNIT ON

SINGLE CHANNEL KINETICS.

Alexandra F. Breitenkamp

, Ajay K.

Singh, Vincent Mortier, Patrick Despang, Marion Brill, Elza Kuzmenkina,

Stefan Herzig

2934-P

os

B

oard

B364

DIVERGENT REGULATION OF CARDIOMYOCYTE CAV1.2

CURRENTS BY CALMODULIN MUTANTS ASSOCIATED WITH

HUMAN SUDDEN DEATH SYNDROMES.

Dmytro O. Kryshtal

,

Hyun S. Hwang, Christopher N. Johnson, Walter J. Chazin, Alfred L.

George Jr., Bjorn C. Knollmann