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Victoria A. Olson Ph.D.
Poxvirus and Rabies Branch
Centers for Disease Control and Prevention
March 22, 2016
Smallpox:
Considerations for testing
DivisionofHigh ConsequencePathogens and Pathology
NationalCenter forEmerging and Zoonotic InfectiousDiseases
Poxvirus 101
Family of large, double stranded
DNA viruses
Within genera, antigenic similarity:
cross protection
Complex viruses, cytoplasmic
lifecycle
Genus
Orthopoxvirus:
90-98% nucleotide identity across
species
Variola, Vaccinia, Cowpox, Monkeypox
–
all can cause human disease
•
Variola
evolved to be a sole human
pathogen: SMALLPOX
Camelpox, Ectromelia, Taterapox
are
NOT known to cause human disease