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Virus eradication –
considerations to 1999
Additional Global Commission sanctioned research –
reflect (new) technologies of the time
Cloning of
Variola virus
genomes – in representative segments
Hybrid viruses* (1981): proof of recombination/“transfection”
•
Scientific Advisory Group of Experts (1984)
o
Vaccine research using
Vaccinia virus
vector
Sequencing of virus genomes –
•
1993 - Two complete
Variola virus
“major”genomes available
Bioterrorism threat once vaccination program ceases
Decision to prohibit genetic manipulation of
Variola
virus
, restrict access to genomic elements and genome
Reports that Russia had attempted to “weaponize”
Variola virus
* Sam and Dumbell Expression of poxvirus DNA in coinfected cells and marker rescue of thermosensitive mutants by subgenomic
fragmentsof DNA Annales de virologie,1981
SMALLPOX RESEARCH AGENDA:
DIAGNOSTICS
WHO/WHA process
IOM 1999, 2009
research 2000 to today