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CRMI is a better predictor of Local
Recurrence after Neo-adjuvant Radiotherapy
• Nagtegaal & Quirke ( 2008 ) :
• Literature review – prognostic significance of CRMI in
publications between 1985 – 2006
• Data available on 17,500 patients
Predictive value of CRMI for local recurrence after multi-
modality treatment greater than after surgery alone:
HR for LR after neo-adjuvant therapy :
6.3
( 3.7 – 16.7 )
HR for LR after surgery :
2.0
( 1.4 – 2.9 )