1158-1159 / 2063
ARCON
•
A
ccelerated
R
adiotherapy +
C
arb
O
gen +
N
icotinamide
42
DD
D D
D
S S
S S
S
S
S
S S
S
S
S
SS
S
S
S
S
S
S
S
D
D
D
D D
DD
D D
S
S
S
S
S
S
S S
SS S
SSS
S
Tumor cell proliferation
D
S
S
S
S
S
S
SS
D
D
D
D
D
D D
D
D D
D
S
S S
S
S
S
S
SS
S
S
S
S
S
S
D
D
D
D
D
D
D
D D
D
S S
SS
S S
SS
SS
S
S
S
S
S
S
S S
S
S
SS
S
S
D
D
D
D
D
D
D
D
D
D
D
D
S
S
S S
S
S
S
S
S
S
DDD
D
DDDD
D
D
D
D D
S
S
S
S
S
S S
S
S
S S
S
S
S S S
S
D S
S D
D
S
S S
S S
S
S
S D D
D
S
S
S
S
D
D
D
D
D
S
S
S
S
S
S
S
SS S
S
S
S
SS
Accelerated fractionation
S
D S
S D
D
S
S S
S S
S
S
S D D
D
S
S
S
S
D
D
D
D
D
S
S
S
S
S
S
S
SS S
S
S
S
SS
S
D
stem cell
differentiated cell
Chronic hypoxia
Carbogen
98% O
2
+ 2% CO
2
Nicotinamide
Acute hypoxia