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Take home messages
•
Hypoxic cell radioresistance is a significant cause of
faillure in local tumor control in particular in SCC of
head and neck and uterine cervix
•
Using high oxygen content gas breathing, chemical
radiosensitizers or blood transfusion have shown
mixed results
•
Meta-analysis of randomized trials does however
demonstrate a significant benefit and level 1a
evidence for head and neck tumors
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