1188-1189 / 2063
Targeting hypoxia – holy grail of radiotherapy?
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Hypoxia targeting has come a long way, from
increasing oxygen supply and enhancing perfusion, to
inhibitors of specific signaling or metabolic pathways
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Tumor hypoxia represents a highly dynamic condition,
distributed heterogenously in tumors and changing over
time
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The concept of acute vs chronic hypoxia is clearly an
oversimplification of a complex condition
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The comeback of large doses/fx or even single doses
also needs consideration of adding relatively non-toxic
hypoxic sensitizers like nimorazole: “back to the future”