Back to the future: SBRT & tumor hypoxia
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With the developments in image-guided radiotherapy
(IGRT), the use of high single doses or a few large
fractions is rapidly gaining popularity in the clinic
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Stereotactic Body RadioTherapy (SBRT) is now widely
used for early stage lung cancer, but also metastases in
various sites
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One reason fractionated radiotherapy became standard
was the absence of a therapeutic window with large
single doses, predominantly because of hypoxia!