1336-1337 / 2063
CHHiP-trial
• Acute toxicity: greater peak for acute bowel toxicity
• Late toxicity: no significant differences between the 74 Gy
and the 60 Gy group
Dearnaley et al. Lancet Oncol.
2016
• Bowel symptoms peaked sooner in hypofractionated
schedules
• RTOG grade 2 or worse bowel toxicity
- 74 Gy: 25%
- 60 Gy: 38%
- 57 Gy: 38%