1576-1577 / 2063
Boosting in situ vaccination effect of RT
•
Pharmacological activation of APCs
because
immunomodulatory effects of RT are often not sufficient to
trigger effective antitumor immune response due to potent
immune suppression in tumor micro-environment and
draining lymph node
•
E.g. agonists of stimulator receptor CD40 and to
TLR
Herrera FG et al CA Cancer J Clin 2017