1572-1573 / 2063
Radioimmunotherapy combinations
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3 main clinical scenario’s
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IT + hypofractionated RT for oligometastatic disease
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Clinical goal: reduce distant failures (effect outside radiation field)
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Mechanism: in situ vaccination effect coupled to local and systemic
effects IT
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IT + chemoRT
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Clinical goal: enhance efficacy of chemo-RT locally and reduce
distant failures
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Mechanism: local and distant synergies between RT and
immunomodulation
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RT + IT
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Clinical goal: maximize efficacy of IT against specific tumor deposit
(effect within radiation field)
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Mechanism: RT = biological response modifier