1564-1565 / 2063
Immune modulation
•
Clinical efficacy of RT
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Traditionally: local effect, through direct tumor cell death
(DNA damage)
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More recently: systemic effects on “out-of-field” tumor
deposits = abscopal effect, mediated by immune
mechanisms
•
RT induces ‘in situ’ vaccination
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RT reprograms the tumor micro-environment
Herrera FG et al CA Cancer J Clin 2017