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Introduction

Changes in normal tissue tolerance with time

Isoeffective dose (Gy)

Time interval (days)

recovery kinetics

repopulation long-term

restoration

spinal cord

oral mucosa

160

140

120

100

80

60

40

20

0

0.00001 0.0001 0.001 0.01 0.1

1

10

100

Long-term recovery

from radiation injury

in some tissues

(not all!)