1686 / 2063
ESTRO
2017
Pelvic radiation with concurrent chemotherapy compared with
pelvic and para-aortic radiation for high-risk cervical cancer.
M. Morris et al, NEJM, 340:1137-1143, 1999.
Enhancement factor
Effect on tumor control
Effect on normal
tissue toxicity
5
4
3
2
1
2
3
4
5
Early
Late
Local
relapse
ESTRO
2017
Treatment of advanced squamous-cell carcinoma of the head
and neck with alternating chemotherapy and radiotherapy.
M. Merlano et al, NEJM, 327:1115-1121, 1992.
Enhancement factor
Effect on tumor control
Effect on normal
tissue toxicity
Early
Late
2
1
2
Local
relapse
?
RT: 70 Gy, 7 weeks
RT+CH: 3 x 20 Gy, 9 weeks;
cddp (20mg/m
2
/d, d1-5)-5Fu (200 mg/m
2
/d, d1-5) x4