1684 / 2063
ESTRO
2017
Modulation of regrowth delay in SA-NH tumor by
fractionated irradiation and fludarabine administration
5
7
9
11
13
15
0 5 10 15 20 25
Time after first fraction (day)
control
Fludarabine
(400 mg/ kg) q.d. x4
4.5 Gy q.d. x4
Fludarabine
3h prior to RT
Mean tumor diameter
± se (mm)
ESTRO
2017
Tumor
radiosensitization
Normal tissue
radio-toxicity
EFFICACY
DMF = 2.0
DMF = 1.2
Therapeutic Ratio = DMF
T
DMF
NT
THE CONCEPT OF THERAPEUTIC RATIO