1679 / 2063
ESTRO
2017
Radio-enhancement by dFdC of a human squamous
cell carcinoma cell line (SQD9)
10 -4
10 -3
10 -2
10 -1
10 0
0 2 4 6 8 10 12 14
Rx alone
dFdC (5 µM) for
3 h prior to Rx
Surviving Fraction
Absorbed dose (Gy)
DMF=1.3
DMF=1.3
DMF=1.3
a b
(Gy
-1
) (Gy
-2
)
Rx
0.30 0.02
Rx + dFdC 0.38 0.04
ESTRO
2017
Rationales for combining chemotherapeutic
agents and ionizing radiation
■
modulation of DNA/chromosome repair
■
regulation of tumor cell proliferation
■
increased tumor cell loss
■
enhancement of nucleoside analogue-
induced apoptosis by IR
■
increased tumor cell re-oxygenation