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ESTRO

2017

Combined chemo- and radiotherapy

treatment

• Spatial co-operation (e.g. breast carcinoma)

• Independent cell kill (e.g. Hodgkin lymphoma)

• Interaction (e.g. H&N, cervix, NSCLC)

• “diluted” toxicity (e.g. Hodgkin lymphoma)

ESTRO

2017

H&N SCC: MACH-NC

Pignon et al.,

Lancet

355: 949-955, 2000