Microsoft Word - RadBio_Programme_ParisSept2017_verAug31

1677 / 2063

ESTRO
2017
DOSE MODIFICATION FACTOR IN SA-NH
TUMOR AFTER SINGLE IRRADIATION COMBINED
WITH FLUDARABINE (800 mg/kg)
RADIATION DOSE (Gy)
GROWTH DELAY ± SE (days)6
8
10
12
14
16
18
20
22
24
19 20 21 22 23 24 25 26 27 28 29
Absolute Growth Delay
DMF = 1.57
Normalized Growth DelayDMF = 1.2
RT alone
ESTRO
2017
1.0E-03
1.0E-02
1.0E-01
1.0E+00 0 5 10 15 20 D 2D
SF1
2SF 1
SF2
Supra-additivity?
Dose (Gy)
S.F.
Combined chemo- and radiotherapy treatment