1787 / 2063
ESTRO
2017
2 weeks ΔADC: +9%: LR
2 weeks: ΔADC: +27%: no LR
D
ADC during RT: result
Courtesy of S. Nuyts
ESTRO
2017
Acronym Stage
Molecular
imaging
Design
Due date
Xuzhou Medical
College, China III-IV§ F-Miso PET
and FDG-PET
RT-CH >< dose escalation on FDG >< dose
escalation on F-Miso
Dec J015?
De Neve*
II-IV FDG-PET 69 Gy IMRT >< 84 Gy IMRT
Q1 2018
Eisbruch*
III-IV DCE-MRI
70 Gy + carbo/cddp >< 80 Gy + carbo/cddp Dec 2020
INTELHOPE* III-IV FDG-PET 66 Gy + cddp >< 73.5 Gy + cddp
Dec 2020
Zips*
III-IV F-Miso PET
70 Gy + CH >< 77 Gy +CH
Dec 2022
Escalox
(Munich)
III
F-Miso PET 70 Gy + CDDP (w1, w5) >< 80.6 Gy +
CDDP (w1, w5)
> July
2015
ClinicalTrials.gov, April 2017
Randomized trials on dose painting / dose
escalation in locally advanced HNSCC
§ nasopharyngeal carcinoma
* randomized phase-II