1850-1851 / 2063
Regrowth delay assay
•
Comparison of growth curves of
treated and untreated tumors
gives the delay caused by
treatment
•
Relationship between growth
delay and surviving fraction of
stem cells is complex
•
Regrowing cells have different
environment: surrounded by
dead and dying cells; vascular
network is already in place
•
Tumor bed effect
Growth Kinetics of Tumors, G.G. Steel, 1977