53 / 2063
9/16/17
8
ESTRO
2017
RTOG 90-03: A Phase III Trial Assessing
Relative Efficacy of Altered Fractionations
1. Conventional Fractionation:
70 Gy / 35 F / 7 W
2. Hyperfractionation:
81.6 Gy / 68 F / 7 W (1.2 Gy/F)
3. Accelerated Fractionation (Split):
67.2 Gy / 42 F / 6 W (2 W Rest)
4. Accelerated Fractionation (CB):
72 Gy / 42 F / 6 W (1.8-1.5 Gy/F)
Stage III & IV
SCC of :
• Oral cavity
• Oropharynx
• Larynx
• Hypopharynx
Stratify :
• No vs N+
• KPS
60-80 VS 90-100
R
A
N
D
O
M
I
Z
E
ESTRO
2017
The “x” Rs of Radiotherapy
• Radiosensitivity
• Repair
• Repopulation
• Redistribution
• Reoxygenation
• iRradiated volume
• Restoration (long term recovery)
• Re-iRRadiation
• another “R” still to be invented…