![Show Menu](styles/mobile-menu.png)
![Page Background](./../common/page-substrates/page0333.jpg)
G1, S and Early G2 checkpoints
•
Rapidly activated after IR
•
Blocks entry into the next cell cycle phase
•
Not important for intrinsic radiosensitivity
•
To single doses!
•
Often altered in cancer
•
Important for avoiding mutations
•
Tumor cells and normal cells proliferate differently after IR
•
Involved in activation of premature senescence